TFF1 P04155

三叶因子 1 (乳腺癌雌激素诱导蛋白) (PNR-2) (多肽 P1.A) (hP1.A) (蛋白 pS2)

功能描述

稳定覆盖胃肠道粘膜的粘液凝胶，提供针对各种有害物质的物理屏障。可能抑制尿液中草酸钙晶体的生长。 {ECO:0000269|PubMed:16308573}。

组织特异性

Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level).

亚细胞定位

Secreted