TFDP2 Q14188

转录因子Dp-2 (E2F二聚化伴侣2)

功能描述

能够刺激E2F依赖的转录。通过E2识别位点5'-TTTC[CG]CGC-3'与E2F家族成员协同结合DNA，该位点存在于许多参与细胞周期调控或DNA复制的基因产物的启动子区域中。TFDP2:E2F复合物在控制细胞周期从G1期向S期进程中起作用。E2F1:DP复合物似乎介导细胞增殖和凋亡。通过抑制CEBPA与其靶基因启动子结合来阻断脂肪细胞分化 (PubMed:20176812)。 {ECO:0000305|PubMed:20176812}。

组织特异性

High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.

亚细胞定位

Nucleus.