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TENM3 Q9P273

张素-3 (Ten-3) (Odd Oz/ten-m同源蛋白3) (肌腱蛋白-M3) (Ten-m3) (张素跨膜蛋白3)

蛋白质信息 (UniProt)

张素-3 (Ten-3) (Odd Oz/ten-m同源蛋白3) (肌腱蛋白-M3) (Ten-m3) (张素跨膜蛋白3)

Q9P273

功能描述

通过调节神经系统内正确连接的建立参与神经发育。作用于海马体的突触前和突触后神经元,控制精确拓扑投射的组装:在CA1和下托神经元中均为近端CA1轴突向远端下托的精确靶向所必需,可能通过促进同嗜性细胞粘附。为脊椎动物视觉系统中正确的树突形态发生和轴突靶向所必需,从而在视觉通路发育中发挥关键作用。调节同侧视网膜图谱在背外侧膝状体核(dLGN)和上丘(SC)中的形成。可能也参与下颌髁突软骨浅层成纤维细胞样细胞分化为软骨细胞。 {ECO:0000250|UniProtKB:Q9WTS6}。

组织特异性

Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus.

亚细胞定位

Cell membrane

关键词

Cell adhesion Cell membrane Cell projection Differentiation Disease variant Disulfide bond EGF-like domain Glycoprotein Membrane Microphthalmia