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TCF20 Q9UGU0

转录因子20 (TCF-20) (核因子SPBP) (蛋白AR1) (基质溶素-1 PDGF反应元件结合蛋白) (SPRE结合蛋白)

蛋白质信息 (UniProt)

转录因子20 (TCF-20) (核因子SPBP) (蛋白AR1) (基质溶素-1 PDGF反应元件结合蛋白) (SPRE结合蛋白)

Q9UGU0

功能描述

转录激活因子,结合MMP3的调控区,从而控制基质溶解素表达。它刺激多种转录激活因子(如JUN、SP1、PAX6和ETS1)的活性,提示其作为共激活因子的功能。{ECO:0000269|PubMed:10995766}。

组织特异性

Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.

亚细胞定位

Nucleus

关键词

Acetylation Activator Alternative splicing Disease variant DNA-binding Intellectual disability Isopeptide bond Metal-binding Methylation Nucleus