转录延伸因子A蛋白样7 (TCEA样蛋白7) (转录延伸因子S-II蛋白样7)
转录延伸因子A蛋白样7 (TCEA样蛋白7) (转录延伸因子S-II蛋白样7)
Q9BRU2功能描述
通过调节NF-kappa-B在其靶基因启动子上的转录活性，在基础水平上负调控NF-kappa-B信号传导。结合含有Myc E-box序列的cyclin D1启动子，并转录抑制cyclin D1的表达。在ALT（端粒替代延长）和端粒酶阳性细胞系中调节端粒酶逆转录酶表达及端粒酶活性。 {ECO:0000269|PubMed:18806825, ECO:0000269|PubMed:19966855, ECO:0000269|PubMed:20454512}.
组织特异性
Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors.
亚细胞定位
Nucleus
关键词