TBC1域家族成员4 (160 kDa Akt底物) (AS160)
TBC1域家族成员4 (160 kDa Akt底物) (AS160)
O60343功能描述
可能作为RAB2A、RAB8A、RAB10和RAB14的GTPase-activating protein。Isoform 2促进胰岛素诱导的葡萄糖转运蛋白SLC2A4/GLUT4在质膜上的易位，从而增加葡萄糖摄取。{ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}。
组织特异性
Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.
亚细胞定位
Cytoplasm
关键词