TBC1D2 Q9BYX2

TBC1域家族成员2A (Armus) (SEREX识别和鉴定的前列腺抗原1) (PARIS-1)

功能描述

作为RAB7A的GTPase激活蛋白。作为连接RAC1和RAB7A的信号效应子，导致RAB7A失活，进而抑制cadherin降解并降低细胞间粘附。 {ECO:0000269|PubMed:20116244}。

组织特异性

Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level).

亚细胞定位

Cytoplasm