TAC4 Q86UU9

速激肽-4 (前速激肽原-C) (PPT-C) [裂解为：内激肽-A (EKA); 内激肽-A/B (EKA/B); 内激肽-C (EKC)]

功能描述

速激肽是活性肽，能兴奋神经元，诱发行为反应，是强效血管舒张剂和促分泌素，并能收缩（直接或间接）许多平滑肌。Endokinin-A在大鼠鞘内给药后诱导热痛觉过敏和疼痛相关行为（如搔抓）。这些效应可通过endokinin-C治疗得到抑制。Endokinin-A/B降低动脉血压并提高精子活力。 {ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:17101218, ECO:0000269|PubMed:17437961, ECO:0000269|PubMed:17655832}。

组织特异性

Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.

亚细胞定位

Secreted