E3泛素蛋白连接酶synoviolin (EC 2.3.2.27) (RING型E3泛素转移酶synoviolin) (滑膜凋亡抑制因子1)
E3泛素蛋白连接酶synoviolin (EC 2.3.2.27) (RING型E3泛素转移酶synoviolin) (滑膜凋亡抑制因子1)
Q86TM6功能描述
E3 ubiquitin-protein ligase，特异性接受来自内质网相关UBC7 E2 ligase的ubiquitin并将其转移至底物，促进其降解 (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:27827840, PubMed:26471130, PubMed:28827405)。内质网质量控制 (ERQC) 系统的组分，该系统也称为内质网相关降解 (ERAD)，参与错误折叠内质网蛋白的ubiquitin依赖性降解 (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558)。亦促进正常但天然短寿蛋白（如SGK）的降解。保护细胞免受内质网应激诱导的凋亡。通过促进多聚谷氨酰胺扩展的huntingtin (HTT) 或未折叠GPR37的降解，保护神经元免受其诱导的凋亡 (PubMed:17141218)。将p53/TP53隔离在细胞质中并促进其降解，从而负向调节其在转录、细胞周期调控和凋亡中的生物学功能 (PubMed:17170702)。介导细胞质NFE2L1的ubiquitination及随后的降解 (By similarity)。在B细胞发育早期，required for pre-B cell receptor (pre-BCR) 复合物的降解，从而支持进一步分化为成熟B细胞 (By similarity)。 {ECO:0000250|UniProtKB:Q9DBY1, ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:16847254, ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:17141218, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:26471130, ECO:0000269|PubMed:27827840, ECO:0000269|PubMed:28827405, ECO:0000269|PubMed:28842558}。
组织特异性
Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level).
亚细胞定位
Endoplasmic reticulum membrane
关键词