突触结合蛋白-4 (突触结合蛋白 IV) (SytIV)
突触结合蛋白-4 (突触结合蛋白 IV) (SytIV)
Q9H2B2功能描述
Synaptotagmin家族成员，不结合Ca(2+) (By similarity) (PubMed:23999003)。通过与KIF1A相互作用参与神经元致密核心囊泡(DCVs)的移动。神经元活动增加时，MAPK8/JNK1的磷酸化作用 destabilizes 与KIF1A的相互作用并将DCVs捕获至突触 (By similarity)。在黑色素细胞树突形成中发挥作用 (PubMed:23999003)。 {ECO:0000250|UniProtKB:P50232, ECO:0000269|PubMed:23999003}。
组织特异性
Expressed in melanocytes (PubMed:23999003). Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus (PubMed:23999003).
亚细胞定位
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane
关键词