联丝蛋白 (Desmuslin)
联丝蛋白 (Desmuslin)
O15061功能描述
VI型中间纤维（IF），在肌细胞细胞骨架中发挥重要的细胞骨架作用。它与结蛋白和/或波形蛋白形成异聚体IF，并通过与细胞骨架蛋白α-抗肌萎缩蛋白、抗肌萎缩蛋白、踝蛋白-1、Utrophin和纽蛋白的相互作用，能够将这些异聚体IF连接到粘附连接，例如横纹肌细胞内的肋节、神经肌肉接头和肌腱连接。 {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}。
组织特异性
Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms.
亚细胞定位
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.
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