SWAP70 Q9UH65

转换相关蛋白 70 (SWAP-70)

功能描述

磷脂酰肌醇3,4,5-三磷酸依赖性鸟嘌呤核苷酸交换因子 (GEF)，其不依赖于RAS，将来自酪氨酸激酶受体的信号转导至RAC。它也介导膜褶皱的信号传导。作为效应蛋白或适配蛋白调节肌动蛋白细胞骨架，以响应激动剂刺激的磷脂酰肌醇(3,4)-二磷酸产生和细胞突起 (By similarity)。 {ECO:0000250, ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}。

组织特异性

Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).

亚细胞定位

Cytoplasm