SVEP1 Q4LDE5

含Sushi、血管性血友病因子A型、EGF和五聚蛋白结构域蛋白1 (含CCP模块蛋白22) (Polydom) (选择素样成骨细胞衍生蛋白) (SEL-OB) (血清学定义乳腺癌抗原NY-BR-38)

功能描述

胚胎发育过程中淋巴管内皮细胞的形态发育、细胞排列和迁移所必需的，可能通过调节ANGPT2-TIE1信号传导及随后激活FOXC2转录 (By similarity)。胚胎淋巴管发育所必需的，通过介导第一个淋巴静脉接触位点的正确形成以及淋巴管内皮与静脉内皮的紧密联系 (By similarity)。通过与整合素的相互作用，抑制血管平滑肌细胞中PRKCA介导的L型电压门控通道Ca(2+)内流和ROCK介导的钙敏感性，从而抑制血管收缩 (PubMed:35802072)。通过与PEAR1相互作用及随后激活AKT/mTOR信号传导，促进血小板活化 (PubMed:36792666)。在表皮发育和角质形成细胞分化中发挥作用，不依赖于细胞间粘附 (PubMed:27892606)。可能在基质成骨细胞的初始细胞附着中发挥作用 (By similarity)。在与整合素ITGA9:ITGB1共存时，可能促进成肌细胞粘附 (By similarity)。 {ECO:0000250|UniProtKB:A2AVA0, ECO:0000269|PubMed:27892606, ECO:0000269|PubMed:35802072, ECO:0000269|PubMed:36792666}。

组织特异性

Expressed in mesenchymal cells (at protein level) (PubMed:16206243). Expressed in vascular smooth muscle cells (at protein level) (PubMed:35802072). Expressed throughout the epidermis, expression is most prominent in the basal and lower suprabasal layers of the epidermis and in dermal fibroblasts in the upper dermis (at protein level) (PubMed:27892606). Abundantly expressed in the placenta, weakly expressed in heart and skeletal muscle (PubMed:11062057, PubMed:27892606). Also expressed in the lung, adrenal gland and cerebellum (PubMed:27892606).

亚细胞定位

Secreted