SUZ12 Q15022

Polycomb蛋白SUZ12 (染色质沉淀E2F靶蛋白9) (ChET 9蛋白) (与JAZF1蛋白融合) (zeste 12蛋白同源抑制因子)

功能描述

Polycomb group (PcG)蛋白。PRC2复合物的组分，该复合物甲基化组蛋白H3的'Lys-9' (H3K9me)和'Lys-27' (H3K27me)，导致受影响靶基因的转录抑制 (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557)。PRC2复合物也可能作为DNA甲基转移酶的募集平台，从而连接两个表观遗传抑制系统 (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464)。被PRC2复合物抑制的基因包括HOXC8、HOXA9、MYT1和CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557)。 {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}。

组织特异性

Overexpressed in breast and colon cancer.

亚细胞定位

Nucleus