转录因子SPT20同源物 (p38相互作用蛋白) (p38IP)
转录因子SPT20同源物 (p38相互作用蛋白) (p38IP)
Q8NEM7功能描述
原肠胚形成过程中MAP激酶p38 (MAPK11, MAPK12, MAPK13和/或MAPK14)激活所必需的。通过在NCK相互作用激酶(NIK)下游调节E-cadherin蛋白水平，且独立于FGF信号传导和Snail对转录的调节，从而在原肠胚形成过程中下调E-cadherin所必需的 (By similarity)。自噬过程中饥饿诱导的ATG9A运输所必需的。 {ECO:0000250, ECO:0000269|PubMed:19893488}。
组织特异性
Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.
亚细胞定位
Nucleus
关键词