胞外硫酸酯酶 Sulf-1 (hSulf-1) (芳基硫酸酯酶) (EC 3.1.6.1) (N-乙酰氨基葡萄糖-6-硫酸酯酶) (EC 3.1.6.14) [切割为：胞外硫酸酯酶 Sulf-2 分泌型]
胞外硫酸酯酶 Sulf-1 (hSulf-1) (芳基硫酸酯酶) (EC 3.1.6.1) (N-乙酰氨基葡萄糖-6-硫酸酯酶) (EC 3.1.6.14) [切割为：胞外硫酸酯酶 Sulf-2 分泌型]
Q8IWU6功能描述
表现出芳基硫酸酯酶活性和高度特异性的内切葡糖胺-6-硫酸酯酶活性 (PubMed:12368295, PubMed:12686563)。它可以从完整肝素特定亚区的葡糖胺C-6位去除硫酸基团 (PubMed:12368295, PubMed:12686563)。降低HSPG (硫酸乙酰肝素蛋白聚糖) 的硫酸化，抑制依赖肝素的生长因子信号传导，减少增殖，并促进外源刺激诱导的细胞凋亡 (PubMed:12686563)。 {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:12686563}。
组织特异性
Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines.
亚细胞定位
Endoplasmic reticulum
关键词