STYK1 Q6J9G0

酪氨酸蛋白激酶STYK1 (EC 2.7.10.2) (含激酶结构域的新型癌基因) (蛋白PK-unique) (丝氨酸/苏氨酸/酪氨酸激酶1)

功能描述

可能的酪氨酸蛋白激酶，对多种细胞系具有强转化能力。当过表达时，它还可以诱导肿瘤细胞侵袭以及远处器官转移。可能通过激活MAP激酶和磷酸肌醇3'-激酶(PI3K)通路起作用（根据相似性）。{ECO:0000250}。

组织特异性

Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.

亚细胞定位

Membrane