STMN1 P16949

Stathmin (白血病相关磷蛋白 p18) (Metablastin) (癌蛋白 18) (Op18) (磷蛋白 p19) (pp19) (Prosolin) (蛋白 Pr22) (pp17)

功能描述

通过使微管不稳定参与微管(MT)丝系统的调节。阻止微管组装并促进微管解聚。Ser-16位的磷酸化可能是神经发生期间轴突形成所必需的。参与习得性恐惧和先天性恐惧的控制(通过相似性)。{ECO:0000250}。

组织特异性

Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

亚细胞定位

Cytoplasm, cytoskeleton.