丝氨酸/苏氨酸蛋白激酶 33 (EC 2.7.11.1)
丝氨酸/苏氨酸蛋白激酶 33 (EC 2.7.11.1)
Q9BYT3功能描述
精子细胞分化和雄性生育能力所必需的丝氨酸/苏氨酸蛋白激酶 (PubMed:37146716, PubMed:38781365)。通过介导纤维鞘蛋白AKAP3和AKAP4的磷酸化，促进精子发生过程中的精子鞭毛组装 (By similarity)。也磷酸化波形蛋白/VIM，从而调节中间丝细胞骨架的动态行为 (By similarity)。 {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}。
组织特异性
Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system.
亚细胞定位
Cytoplasm
关键词