双链RNA结合蛋白Staufen同源物2
双链RNA结合蛋白Staufen同源物2
Q9NUL3功能描述
RNA结合蛋白，为微管依赖性的神经元RNA从细胞体向树突运输所必需。由于蛋白质合成发生在树突内，特定mRNA定位到树突可能是远离细胞体的部位发生神经突生长和可塑性的先决条件（通过相似性）。 {ECO:0000250|UniProtKB:Q68SB1}。
亚细胞定位
Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity).
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