STAG2 Q8N3U4

黏连蛋白亚基 SA-2 (SCC3同源物 2) (基质抗原 2)

功能描述

Cohesin复合物的组分，该复合物是DNA复制后姐妹染色单体凝聚所必需的。Cohesin复合物显然形成了一个巨大的蛋白环，姐妹染色单体可被捕获其中。在后期，该复合物被切割并从染色质解离，从而允许姐妹染色单体分离。Cohesin复合物在有丝分裂期间可能还参与纺锤体极的组装。 {ECO:0000269|PubMed:12034751}。

亚细胞定位

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.