CMP-N-乙酰神经氨酸-聚-α-2,8-唾液酸转移酶 (EC 2.4.3.-) (α-2,8-唾液酸转移酶 8D) (聚唾液酸转移酶) (聚唾液酸转移酶-1) (唾液酸转移酶 8D) (SIAT8-D) (唾液酸转移酶 St8Sia IV) (ST8SiaIV)
CMP-N-乙酰神经氨酸-聚-α-2,8-唾液酸转移酶 (EC 2.4.3.-) (α-2,8-唾液酸转移酶 8D) (聚唾液酸转移酶) (聚唾液酸转移酶-1) (唾液酸转移酶 8D) (SIAT8-D) (唾液酸转移酶 St8Sia IV) (ST8SiaIV)
Q92187功能描述
催化唾液酸从CMP连接的唾液酸供体转移至N-连接聚糖蛋白受体的末端alpha-2,3-、alpha-2,6-或alpha-2,8-连接的唾液酸上，通过alpha-2,8-连接键 (PubMed:10766765, PubMed:11279095, PubMed:28810663, PubMed:9774483)。因此，参与各种唾液酸化N-乙酰乳糖胺基寡糖上的多聚唾液酸合成，包括NCAM1 N-聚糖、FETUB N-聚糖和AHSG (PubMed:10766765, PubMed:11279095, PubMed:28810663, PubMed:9774483)。值得注意的是，alpha-2,3-连接的唾液酸显然是比alpha-2,6-连接的唾液酸更好的受体 (PubMed:9774483)。 {ECO:0000269|PubMed:10766765, ECO:0000269|PubMed:11279095, ECO:0000269|PubMed:28810663, ECO:0000269|PubMed:9774483}。
组织特异性
Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus (PubMed:7624364). Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes (PubMed:7624364).
亚细胞定位
Golgi apparatus membrane
关键词