SSTR2 P30874

生长抑素受体2型 (SS-2-R) (SS2-R) (SS2R) (SST2) (SRIF-1)

功能描述

生长抑素-14和-28的受体。该受体通过百日咳毒素敏感的G蛋白偶联，抑制腺苷酸环化酶。此外，它还通过百日咳毒素不敏感及敏感的G蛋白刺激磷酸酪氨酸磷酸酶和PLC。通过抑制电压依赖性钙通道来抑制钙内流。作为胰腺α和β细胞中功能显性的生长抑素受体，介导生长抑素-14对激素分泌的抑制作用。通过增强MAPK1和MAPK2磷酸化以及随后的CDKN1B上调来抑制细胞生长。刺激神经元迁移和轴突生长，并可能参与大脑发育过程中的神经元发育和成熟。通过PTPN6介导胰岛素受体信号的负调控。异源二聚化后使SSTR3受体功能失活。 {ECO:0000269|PubMed:15231824, ECO:0000269|PubMed:18653781, ECO:0000269|PubMed:19434240, ECO:0000269|PubMed:22495673, ECO:0000269|PubMed:22932785}。

组织特异性

Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.

亚细胞定位

Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.