蛋白磷酸酶弹弓同源物1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH样蛋白1) (SSH-1L) (hSSH-1L)
蛋白磷酸酶弹弓同源物1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH样蛋白1) (SSH-1L) (hSSH-1L)
Q8WYL5功能描述
蛋白磷酸酶，调节肌动蛋白丝动力学。使肌动蛋白结合/解聚因子cofilin去磷酸化并激活，后者随后结合肌动蛋白丝并刺激其解聚。Cofilin的抑制性磷酸化由LIMK1介导，LIMK1也可能被该蛋白去磷酸化并失活。 {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}.
亚细胞定位
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.
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