SRPX2 O60687

含Sushi重复蛋白SRPX2 (白血病中上调的Sushi重复蛋白)

功能描述

作为尿激酶纤溶酶原激活物表面受体的配体。通过诱导内皮细胞迁移和血管网络（索）的形成，在血管生成中发挥作用。参与细胞迁移和粘附。增加FAK的磷酸化水平。与HGF相互作用并增加其促有丝分裂活性。促进突触形成。可能在围外侧裂区具有作用，该区域对语言和认知发育至关重要。 {ECO:0000269|PubMed:16497722, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:19065654, ECO:0000269|PubMed:24179158}。

组织特异性

Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa.

亚细胞定位

Secreted