SRGAP3 O43295

SLIT-ROBO Rho GTPase激活蛋白3 (srGAP3) (精神障碍相关GAP) (Rho GTPase激活蛋白14) (WAVE相关Rac GTPase激活蛋白) (WRP)

蛋白质信息 (UniProt)

SLIT-ROBO Rho GTPase激活蛋白3 (srGAP3) (精神障碍相关GAP) (Rho GTPase激活蛋白14) (WAVE相关Rac GTPase激活蛋白) (WRP)

O43295

功能描述

RAC1及可能Cdc42的GTPase-activating protein，但对RhoA小GTPase无作用。可能在神经元中减弱RAC1信号传导。 {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}。

组织特异性

Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.

关键词

Alternative splicing Chromosomal rearrangement Coiled coil GTPase activation Phosphoprotein Proteomics identification Reference proteome SH3 domain

UniProt: O43295

NCBI Gene

GeneCards