多聚异戊二烯还原酶 (EC 1.3.1.94) (3-氧代-5-α-类固醇4-脱氢酶3) (EC 1.3.1.22) (类固醇5-α-还原酶2样) (类固醇5-α-还原酶3) (S5AR 3) (SR type 3)
多聚异戊二烯还原酶 (EC 1.3.1.94) (3-氧代-5-α-类固醇4-脱氢酶3) (EC 1.3.1.22) (类固醇5-α-还原酶2样) (类固醇5-α-还原酶3) (S5AR 3) (SR type 3)
Q9H8P0功能描述
通过参与多聚异戊二烯醇向长醇的转化，在蛋白质N-连接糖基化的早期步骤中发挥关键作用 (PubMed:20637498, PubMed:38821050)。作为一种多聚异戊二烯醛还原酶，以依赖NADP的机制催化多聚异戊二烯醛还原为长醇醛 (PubMed:38821050)。长醇是合成用于N-糖基化的长醇连接单糖和寡糖前体所必需的 (PubMed:20637498, PubMed:38821050)。也能够将睾酮 (T) 转化为5α-双氢睾酮 (DHT) (PubMed:17986282, PubMed:26855069)。 {ECO:0000269|PubMed:17986282, ECO:0000269|PubMed:20637498, ECO:0000269|PubMed:26855069, ECO:0000269|PubMed:38821050}。
组织特异性
Expressed in preadipocytes (at protein level) (PubMed:26855069). Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs.
亚细胞定位
Endoplasmic reticulum membrane
关键词