类固醇受体RNA激活因子1 (类固醇受体RNA激活蛋白) (SRAP)
类固醇受体RNA激活因子1 (类固醇受体RNA激活蛋白) (SRAP)
Q9HD15功能描述
功能性RNA，作为转录共激活因子，通过涉及类固醇受体调节N端结构域(AF-1)的机制，配体非依赖性地选择性增强类固醇受体介导的反式激活。亦通过类固醇结合结构域(AF-2)配体依赖性地介导类固醇受体的转录共激活。增强细胞增殖和分化，并在体内促进凋亡。可能在肿瘤发生中发挥作用。 {ECO:0000269|PubMed:10199399, ECO:0000269|PubMed:12943696, ECO:0000269|PubMed:14517287, ECO:0000269|PubMed:15147866, ECO:0000269|PubMed:15351741}。
组织特异性
Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus.
亚细胞定位
Nucleus
关键词