SPRY1 O43609

Sprouty同源蛋白1 (Spry-1)

功能描述

抑制成纤维细胞生长因子 (FGF) 诱导的视网膜晶状体纤维分化，可能是通过抑制 FGF 介导的 ERK1/2 磷酸化 (By similarity)。抑制 TGFB 诱导的晶状体上皮细胞上皮-间质转化 (By similarity)。 {ECO:0000250|UniProtKB:Q9QXV9}。

亚细胞定位

Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).