Speedy蛋白A (卵母细胞G2/M期进程快速诱导因子A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1)
Speedy蛋白A (卵母细胞G2/M期进程快速诱导因子A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1)
Q5MJ70功能描述
通过结合并激活CDK1和CDK2调节细胞周期的G1/S期转换 (PubMed:12972555)。通过诱导CDK2 T-loop的构象变化，在激酶激活前阻碍底物结合裂口，从而在不促进CDK2磷酸化的情况下促进CDK2激活 (PubMed:28666995)。通过激活CDK2在DNA损伤过程中介导细胞存活 (PubMed:12839962)。 {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555, ECO:0000269|PubMed:28666995}.
组织特异性
Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase.
亚细胞定位
Nucleus
关键词