SPDL1 Q96EA4

Spindly蛋白 (hSpindly) (砷相关基因1蛋白) (含卷曲螺旋结构域蛋白99) (横纹肌肉瘤抗原MU-RMS-40.4A) (纺锤体装置含卷曲螺旋结构域蛋白1)

功能描述

为dynein和dynactin定位于有丝分裂动粒所必需。Dynein被认为控制动粒与纺锤体微管之间的初始侧向相互作用，并促进随后由NDC80复合物介导的动粒-微管末端连接的形成。也是正确的纺锤体取向所必需的。似乎并不为双极纺锤体附着后从动粒上移除纺锤体组装检查点(SAC)蛋白所必需(PubMed:17576797, PubMed:19468067)。作为适配蛋白将dynein马达复合物连接到各种货物，并在dynactin存在下将dynein从非持续运动性马达转变为高度持续运动性马达。促进dynein和dynactin之间的相互作用并激活dynein的持续运动性（沿微管长距离移动而不脱离轨道的能力）(PubMed:25035494)。在细胞迁移中发挥作用(PubMed:30258100)。 {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:30258100}。

亚细胞定位

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.