SPATA2 Q9UM82

精子发生相关蛋白 2

功能描述

介导CYLD招募至LUBAC复合物的桥接因子，从而调节TNF诱导的程序性坏死 (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049)。作为直接结合中间体，桥接LUBAC复合物的催化亚基RNF31/HOIP与去泛素化酶 (CYLD)，从而将CYLD招募至TNF-R1信号复合物 (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049)。激活CYLD的'Met-1'- (线性) 和'Lys-63'-连接的去泛素化酶活性所必需 (PubMed:27458237, PubMed:27591049)。通过促进CYLD对RIPK1的'Met-1'-连接去泛素化，控制RIPK1的激酶活性和TNF诱导的程序性坏死 (By similarity)。 {ECO:0000250|UniProtKB:Q8K004, ECO:0000269|PubMed:27307491, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27545878, ECO:0000269|PubMed:27591049}。

组织特异性

Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level) (PubMed:10222154, PubMed:11079456). Low expression in spleen, thymus and prostate (PubMed:10222154).

亚细胞定位

Cytoplasm