SP3 Q02447

转录因子Sp3 (SPR-2)

蛋白质信息 (UniProt)

转录因子Sp3 (SPR-2)

Q02447

功能描述

转录因子，根据同工型和/或翻译后修饰的不同，可作为激活因子或阻遏因子发挥作用。结合GT和GC盒启动子元件。与SP1竞争GC盒启动子。转录的弱激活因子，但可激活涉及不同过程（如细胞周期调控、激素诱导和持家）的多种基因。 {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}。

组织特异性

Ubiquitously expressed.

亚细胞定位

Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.

关键词

Acetylation Activator Alternative initiation Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification

外部链接

UniProt: Q02447

NCBI Gene

GeneCards