SOX7 Q9BT81

转录因子 SOX-7

功能描述

结合并激活CDH5启动子，因此在造血内皮中表达的基因的转录调控中发挥作用，并阻断向血液前体细胞的进一步分化 (By similarity)。可能在特化过程中造血和内皮前体细胞的存活中是必需的 (By similarity)。与GATA4竞争结合并激活FGF3启动子 (By similarity)。抑制Wnt/beta-catenin刺激的转录，可能是通过靶向CTNNB1进行蛋白酶体降解。结合DNA序列5'-AACAAT-3'。 {ECO:0000250, ECO:0000269|PubMed:18819930}。

组织特异性

Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.

亚细胞定位

Nucleus