SOX13 Q9UN79

转录因子SOX-13 (胰岛细胞抗原12) (SRY (Y染色体性别决定区)-盒13) (1型糖尿病自身抗原ICA12)

功能描述

转录因子，结合DNA共有序列5'-AACAAT-3' (PubMed:10871192)。结合髓鞘蛋白MPZ基因的近端启动子区域，可能借此参与发育中脊髓管内少突胶质细胞的分化 (By similarity)。结合MBP的基因启动子并作为转录抑制因子发挥作用 (By similarity)。结合TCF7/TCF1并调节其活性，从而抑制转录并调节正常的gamma-delta T细胞发育和表达IL17A的gamma-delta T细胞的分化 (By similarity)。在表达IL17A的gamma-delta T细胞的分化过程中调节BLK的表达 (By similarity)。促进棕色脂肪细胞分化 (By similarity)。WNT信号通路的抑制剂 (PubMed:20028982)。 {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}。

组织特异性

Expressed in exocrine cells and islets of Langerhans in the pancreas (at protein level) (PubMed:10871192). Expressed in the pancreas, placenta, kidney, brain, heart, lung, and liver (PubMed:10871192, PubMed:20028982). Expressed in adipose tissue, cervix, colon, esophagus, ovary, prostate, small intestine, spleen, testicle, thymus and thyroid (PubMed:20028982).

亚细胞定位

Nucleus