SOX12 O15370

转录因子 SOX-12 (蛋白 SOX-22)

功能描述

转录因子，结合DNA共有序列5'-ACCAAAG-3' (By similarity)。作为转录激活因子发挥作用 (By similarity)。与POU3F2/BRN2或POU3F1/OCT6协同结合基因启动子，从而增强转录激活 (By similarity)。参与炎症条件下naive CD4-positive T细胞分化为外周诱导调节性T (pT reg) 细胞的过程 (By similarity)。结合FOXP3基因的启动子区域并促进其转录，可能借此在炎症期间促进脾脏和淋巴结中pT reg细胞的分化 (By similarity)。与SOX4和SOX11在神经管、鳃弓和体节等发育组织的细胞存活中发挥冗余作用，从而促进器官发生 (By similarity)。 {ECO:0000250|UniProtKB:Q04890}。

组织特异性

Expressed most abundantly in the CNS (PubMed:9215677). Expressed in the heart, pancreas, thymus, testis and ovary (PubMed:9215677). Weakly expressed in brain, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, small intestine, colon, and peripheral blood lymphocytes (PubMed:9215677).

亚细胞定位

Nucleus