含VPS10结构域受体SorCS2 [切割为：SorCS2 122 kDa链；SorCS2 104 kDa链；SorCS2 18 kDa链]
含VPS10结构域受体SorCS2 [切割为：SorCS2 122 kDa链；SorCS2 104 kDa链；SorCS2 18 kDa链]
Q96PQ0功能描述
由NGFR和SORCS2形成的异二聚体作为NGF前体形式(proNGF)和BDNF前体形式(proBDNF)的受体 (PubMed:22155786, PubMed:24908487)。ProNGF和proBDNF结合均促进轴突生长锥塌陷 (体外) (PubMed:22155786, PubMed:24908487)。在海马神经元树突棘密度的调节中起作用 (By similarity)。BDNF响应中的正常神经突分支和延伸所必需 (PubMed:27457814)。在BDNF依赖性海马突触可塑性中起作用。与NGFR和NTRK2一起，是BDNF介导的突触长时程抑制和长时程增强所必需的 (PubMed:27457814)。ProNGF结合促进TRIO与异二聚体解离，导致RAC1和/或RAC2失活及随后的肌动蛋白细胞骨架重组 (PubMed:22155786)。与retromer复合体亚基VPS35一起，是突触和树突细胞膜上GRIN2A正常表达所必需的。是细胞膜上氨基酸转运蛋白SLC1A1正常表达所必需的，从而有助于保护细胞免受氧化应激 (By similarity)。 {ECO:0000250|UniProtKB:Q9EPR5, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:27457814}.; FUNCTION: [SorCS2 122 kDa链]: 不促进Schwann细胞响应proBDNF的凋亡。 {ECO:0000269|PubMed:24908487}.; FUNCTION: SorCS2 104 kDa链和SorCS2 18 kDa链共同促进Schwann细胞响应proBDNF的凋亡。 {ECO:0000269|PubMed:24908487}.
组织特异性
Detected on neurons in the caudate region (PubMed:28469074). Detected on neurons in the hippocampus (at protein level) (PubMed:30840898). Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus (PubMed:11499680).
亚细胞定位
Cell membrane
关键词