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SORBS3 O60504

Vinexin (含SH3适配分子1) (SCAM-1) (Sorbin和SH3结构域包含蛋白3)

蛋白质信息 (UniProt)

Vinexin (含SH3适配分子1) (SCAM-1) (Sorbin和SH3结构域包含蛋白3)

O60504

功能描述

Vinexin alpha isoform 促进肌动蛋白应力纤维形成的上调。Vinexin beta isoform 在细胞铺展中发挥作用,并利用其第三个 SH3 domain 增强响应 EGF 刺激的 JNK/SAPK 激活。

组织特异性

Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.

亚细胞定位

[Isoform Alpha]: Cell junction

关键词

3D-structure Acetylation Alternative splicing Cell adhesion Cell junction Cytoplasm Cytoskeleton Nucleus Phosphoprotein Proteomics identification