SORBS2 O94875

Sorbin和SH3结构域包含蛋白2 (Arg结合蛋白2) (ArgBP2) (Arg/Abl相互作用蛋白2) (Sorbin)

功能描述

作为适配蛋白，在信号复合物的组装中发挥作用，是ABL激酶与肌动蛋白细胞骨架之间的连接纽带。能与ABL1和CBL形成复合物，从而促进ABL1的泛素化和降解。可能在胰腺细胞粘附的调节中发挥作用，可能通过作用于WASF1磷酸化，增强ABL1介导的磷酸化以及PTPN12介导的去磷酸化 (PubMed:18559503)。Isoform 6增加肠道和胆囊中水和钠的吸收。 {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}。

组织特异性

Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. In the pancreas, mainly expressed in acinar cells, duct cells and all cell types in islets (at protein level). Tends to be down-regulated in pancreatic adenocarcinomas and metastases.

亚细胞定位

Cytoplasm, perinuclear region