分选微管连接蛋白-9 (SH3和PX结构域包含蛋白1) (蛋白SDP1) (SH3和PX结构域包含蛋白3A)
分选微管连接蛋白-9 (SH3和PX结构域包含蛋白1) (蛋白SDP1) (SH3和PX结构域包含蛋白3A)
Q9Y5X1功能描述
参与胞吞和细胞内囊泡运输，包括分裂间期和有丝分裂末期。为有效完成有丝分裂和胞质分裂所必需。为有丝分裂末期分裂沟的正常形成所必需。在网格蛋白包被凹陷介导的胞吞中起作用，同时也参与不依赖网格蛋白、依赖肌动蛋白的液相胞吞。在巨胞饮中起作用。促进TNFR的内化。促进EGF信号传导后EGFR的降解。刺激DNM1的GTPase活性。促进DNM1寡聚化。促进WASL激活Arp2/3复合体，从而在F-actin细胞骨架重组中起作用。结合富含磷脂酰肌醇4,5-二磷酸的膜并促进膜管形成。对富含磷脂酰肌醇3-磷酸的膜亲和力较低。 {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}。
组织特异性
Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes.
亚细胞定位
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
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