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SNRPE P62304

小核核糖核蛋白 E (snRNP-E) (Sm蛋白 E) (Sm-E) (SmE)

蛋白质信息 (UniProt)

小核核糖核蛋白 E (snRNP-E) (Sm蛋白 E) (Sm-E) (SmE)

P62304

功能描述

作为剪接体U1、U2、U4和U5小核核糖核蛋白(snRNP)的核心成分,在pre-mRNA剪接中发挥作用,这些snRNP是剪接体的构建单元(PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23246290, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006)。是催化前剪接体B复合物和活化剪接体C复合物的成分(PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166)。作为次要剪接体的成分,参与pre-mRNA中U12型内含子的剪接(PubMed:15146077)。作为U7 snRNP的一部分,参与组蛋白3'端加工(PubMed:12975319)。 {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12975319, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23246290, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}。

组织特异性

Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.

亚细胞定位

Cytoplasm, cytosol

关键词

3D-structure Cytoplasm Disease variant Hypotrichosis mRNA processing mRNA splicing Nucleus Proteomics identification Reference proteome Ribonucleoprotein