SNAI2 O43623

锌指蛋白SNAI2 (神经嵴转录因子Slug) (蛋白snail同源物2)

功能描述

转录抑制因子，调节激活因子依赖性和基础转录。参与神经嵴细胞的生成和迁移。在介导RAF1诱导的TJ蛋白occludin (OCLN)转录抑制以及随后的上皮细胞致癌转化中发挥作用 (By similarity)。在乳腺细胞中，通过结合BRCA2的含E2-box沉默子并招募CTBP1和HDAC1来抑制BRCA2表达。在表皮角质形成细胞中，结合ITGA3启动子中的E-box并抑制其转录。参与表皮角质形成细胞中ITGB1和ITGB4表达的调节以及细胞粘附和增殖。在肝细胞TGFB1诱导的上皮-间质转化 (EMT) 过程中，结合BSG的E-box2结构域并激活其表达。通过E-box元件抑制E-Cadherin/CDH1转录。参与成骨细胞成熟。结合RUNX2和SOC9启动子，在成骨细胞中可能分别作为正性和负性转录调节因子发挥作用。在间充质干细胞和成骨细胞中通过E-box区域结合CXCL12启动子。在TWIST1诱导的EMT及其促进侵袭和转移的能力中发挥重要作用。 {ECO:0000250, ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:11912130, ECO:0000269|PubMed:15734731, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}。

组织特异性

Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).

亚细胞定位

Nucleus