SLCO1B1 Q9Y6L6

溶质载体有机阴离子转运蛋白家族成员1B1 (SLCO1B1) (肝脏特异性有机阴离子转运蛋白1) (LST-1) (OATP-C) (有机阴离子转运蛋白SLC21A6) (非钠依赖性有机阴离子转运多肽2) (OATP-2) (溶质载体家族21成员6)

功能描述

介导有机阴离子的Na(+)-非依赖性摄取 (PubMed:10358072, PubMed:15159445, PubMed:17412826)。显示出广泛的底物特异性，可以转运有机阴离子，如胆汁酸牛磺胆酸 (cholyltaurine) 和结合类固醇 (脱氢表雄酮3-硫酸、17-β-葡萄糖醛酸雌二醇和雌酮3-硫酸)，以及类二十烷酸 (前列腺素E2、血栓素B2、白三烯C4和白三烯E4) 和甲状腺激素 (T4/L-甲状腺素和T3/3,3',5'-三碘-L-甲状腺原氨酸) (PubMed:10358072, PubMed:10601278, PubMed:10873595, PubMed:11159893, PubMed:12196548, PubMed:12568656, PubMed:15159445, PubMed:15970799, PubMed:16627748, PubMed:17412826, PubMed:19129463, PubMed:26979622)。可以从血浆中摄取胆红素葡萄糖醛酸进入肝脏，有助于增强解毒的肝-血穿梭循环 (PubMed:22232210)。参与肝脏内源性和外源性底物的清除 (PubMed:10358072, PubMed:10601278)。转运粪卟啉I和III（血红素合成的副产物），并可能参与其肝脏处置 (PubMed:26383540)。可能有助于调节睾丸跨血睾屏障的有机化合物转运 (Probable)。可以转运HMG-CoA还原酶抑制剂（也称为他汀类药物），如普伐他汀和匹伐他汀，这是一类临床重要的降脂药物 (PubMed:10601278, PubMed:15159445, PubMed:15970799)。可能在结构多样化的化疗药物甲氨蝶呤的血浆和组织分布中起重要作用 (PubMed:23243220)。也可能在肝脏中转运抗高血压药物，如血管紧张素转化酶 (ACE) 抑制剂前药依那普利，以及高选择性的血管紧张素II AT1受体拮抗剂缬沙坦 (PubMed:16624871, PubMed:16627748)。显示出对前列腺素E2和T4的pH敏感底物特异性，这可能归因于结合位点的质子化状态，并导致在酸性微环境中底物转运受到刺激 (PubMed:19129463)。碳酸氢根/HCO3(-) 充当可能的反向阴离子，与有机阴离子进行交换 (PubMed:19129463)。 {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:12568656, ECO:0000269|PubMed:15159445, ECO:0000269|PubMed:15970799, ECO:0000269|PubMed:16624871, ECO:0000269|PubMed:16627748, ECO:0000269|PubMed:17412826, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:22232210, ECO:0000269|PubMed:23243220, ECO:0000269|PubMed:26383540, ECO:0000269|PubMed:26979622, ECO:0000305|PubMed:35307651}。

组织特异性

Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes (PubMed:10358072, PubMed:10601278, PubMed:10873595, PubMed:12196548, PubMed:22232210). Expressed in liver (at protein level) (PubMed:15159445). Expressed in fetal liver (PubMed:10873595). Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte (PubMed:10358072, PubMed:10873595). In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and within the tubules (PubMed:35307651).

亚细胞定位

Basolateral cell membrane