SLC8A1 P32418

钠/钙交换蛋白1 (Na(+)/Ca(2+)-交换蛋白1) (溶质载体家族8成员1)

功能描述

介导跨细胞膜交换一个Ca(2+)离子与三到四个Na(+)离子，从而有助于调节细胞质Ca(2+)水平和依赖Ca(2+)的细胞过程 (PubMed:11241183, PubMed:1374913, PubMed:1476165)。有助于肌肉兴奋-收缩偶联期间的Ca(2+)转运 (PubMed:11241183, PubMed:1374913, PubMed:1476165)。在第一阶段，电压门控通道介导细胞质Ca(2+)水平的快速升高，这是由于内质网Ca(2+)库的释放 (PubMed:11241183, PubMed:1374913, PubMed:1476165)。SLC8A1在下一阶段介导Ca(2+)从细胞输出，从而使细胞质Ca(2+)水平迅速恢复到基线 (PubMed:11241183, PubMed:1374913, PubMed:1476165)。正常胚胎心脏发育和心脏收缩起始所必需 (By similarity)。 {ECO:0000250|UniProtKB:P70414, ECO:0000269|PubMed:11241183, ECO:0000269|PubMed:1374913, ECO:0000269|PubMed:1476165}。

组织特异性

Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165).

亚细胞定位

Cell membrane