SLC5A8 Q8N695

钠偶联单羧酸转运蛋白 1 (顶端碘转运蛋白) (生电性钠单羧酸协同转运蛋白) (钠碘相关协同转运蛋白) (溶质载体家族 5 成员 8)

功能描述

作为生电性钠(Na(+))和氯(Cl-)依赖性钠偶联溶质转运蛋白发挥作用，包括转运单羧酸（短链脂肪酸，包括L-乳酸、D-乳酸、丙酮酸、乙酸、丙酸、戊酸和丁酸）、单羧酸药物（烟酸、苯甲酸、水杨酸和5-氨基水杨酸）和酮体（β-D-羟基丁酸、乙酰乙酸和α-酮异己酸），Na(+):底物化学计量比在4:1到2:1之间 (PubMed:14966140, PubMed:15090606, PubMed:16729224, PubMed:16805814, PubMed:17178845, PubMed:17245649, PubMed:17526579, PubMed:20211600, PubMed:30604288)。催化碘离子的被动载体介导扩散 (PubMed:12107270)。通过顶膜介导碘离子从甲状腺细胞转运进入胶体腔 (PubMed:12107270)。可能负责从肠道吸收D-乳酸和单羧酸药物 (PubMed:17245649)。作为肿瘤抑制因子，抑制结肠癌、前列腺癌和神经胶质瘤细胞系的集落形成 (PubMed:12829793, PubMed:15867356, PubMed:18037591)。可能通过由电化学Na(+)梯度驱动的过程，在L-乳酸和酮体进入神经元的过程中发挥关键作用，从而有助于维持神经元的能量状态和功能 (PubMed:16805814)。介导焦谷氨酸（5-氧-L-脯氨酸）的钠偶联生电转运 (PubMed:20211600)。当钠离子外部浓度降低时，能介导氯、溴、碘和硝酸根离子的转运 (PubMed:19864324)。 {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:12829793, ECO:0000269|PubMed:14966140, ECO:0000269|PubMed:15090606, ECO:0000269|PubMed:15867356, ECO:0000269|PubMed:16729224, ECO:0000269|PubMed:16805814, ECO:0000269|PubMed:17178845, ECO:0000269|PubMed:17245649, ECO:0000269|PubMed:17526579, ECO:0000269|PubMed:18037591, ECO:0000269|PubMed:19864324, ECO:0000269|PubMed:20211600, ECO:0000269|PubMed:30604288}。

组织特异性

Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors.

亚细胞定位

Apical cell membrane