SLC5A5 Q92911

钠/碘同向转运蛋白 (Na(+)/I(-) 同向转运蛋白) (钠碘转运蛋白) (钠-碘同向转运蛋白) (Na(+)/I(-) 同向转运蛋白) (溶质载体家族5成员5)

蛋白质信息 (UniProt)

钠/碘同向转运蛋白 (Na(+)/I(-) 同向转运蛋白) (钠碘转运蛋白) (钠-碘同向转运蛋白) (Na(+)/I(-) 同向转运蛋白) (溶质载体家族5成员5)

Q92911

功能描述

钠:碘同向转运蛋白，介导碘化物转运进入甲状腺 (PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:20797386, PubMed:31310151, PubMed:32084174, PubMed:8806637, PubMed:9329364)。也能介导氯酸、硫氰酸、硝酸和硒氰酸的转运 (PubMed:12488351)。 {ECO:0000269|PubMed:12488351, ECO:0000269|PubMed:18372236, ECO:0000269|PubMed:18708479, ECO:0000269|PubMed:20797386, ECO:0000269|PubMed:31310151, ECO:0000269|PubMed:32084174, ECO:0000269|PubMed:8806637, ECO:0000269|PubMed:9329364}。

组织特异性

Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.

亚细胞定位

Cell membrane

关键词

Cell membrane Congenital hypothyroidism Cytoplasm Direct protein sequencing Disease variant Glycoprotein Ion transport Membrane Metal-binding Phosphoprotein

外部链接

UniProt: Q92911

NCBI Gene

GeneCards