有机溶质转运蛋白亚基α (OST-alpha) (溶质载体家族51亚基α)
有机溶质转运蛋白亚基α (OST-alpha) (溶质载体家族51亚基α)
Q86UW1功能描述
Ost-alpha/Ost-beta复合物的必需组分，该复合物是一种异二聚体，作为肠基底侧转运蛋白，负责将胆汁酸从肠细胞输出到门静脉血中 (PubMed:16317684)。高效转运主要种类的胆汁酸（牛磺胆酸）(PubMed:16317684)。牛磺酸结合物跨基底侧膜的转运效率高于甘氨结合胆汁酸 (By similarity)。还能转运类固醇，如雌酮3-硫酸和脱氢表雄酮3-硫酸，因此在类固醇的肠肝循环中发挥作用 (PubMed:16317684)。能够转运类二十烷酸，如前列腺素E2 (By similarity)。 {ECO:0000250|UniProtKB:Q8R000, ECO:0000250|UniProtKB:Q90YM5, ECO:0000269|PubMed:16317684}。
组织特异性
Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
亚细胞定位
Cell membrane
关键词