氨基酸转运蛋白重链 SLC3A2 (4F2 细胞表面抗原重链) (4F2hc) (4F2 重链抗原) (淋巴细胞激活抗原 4F2 大亚基) (溶质载体家族 3 成员 2) (CD 抗原 CD98)
氨基酸转运蛋白重链 SLC3A2 (4F2 细胞表面抗原重链) (4F2hc) (4F2 重链抗原) (淋巴细胞激活抗原 4F2 大亚基) (溶质载体家族 3 成员 2) (CD 抗原 CD98)
P08195功能描述
作为一种分子伴侣，促进功能性转运蛋白异二聚体的生物合成和向质膜的转运。与SLC7家族转运蛋白（SLC7A5、SLC7A6、SLC7A7、SLC7A8、SLC7A10和SLC7A11）形成异二聚体，这是一组氨基酸反向转运蛋白 (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049)。异二聚体作为氨基酸交换蛋白发挥作用，底物的特异性取决于SLC7A亚基。异二聚体SLC3A2/SLC7A6或SLC3A2/SLC7A7介导二碱基氨基酸的摄取 (PubMed:10903140, PubMed:9829974)。异二聚体SLC3A2/SLC7A11作为反向转运蛋白发挥作用，通过介导细胞外阴离子L-胱氨酸和细胞内L-谷氨酸跨细胞质膜的交换 (PubMed:34880232)。SLC3A2/SLC7A10转运小的中性L-型和D-型氨基酸跨过质膜 (By similarity)。SLC3A2/SLC75或SLC3A2/SLC7A8转运具有广泛特异性的中性氨基酸、甲状腺激素和L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168)。SLC3A2对于SLC7A5和SLC7A8的质膜定位、稳定性和转运活性至关重要 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406)。当与LAPTM4B结合时，异二聚体SLC7A5被募集到溶酶体以促进亮氨酸摄取进入这些细胞器，从而介导mTORC1激活 (PubMed:25998567)。调节整合素相关信号传导，对于整合素依赖性的细胞铺展、迁移和肿瘤进展至关重要 (PubMed:11121428, PubMed:15625115)。 {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) 在丙型肝炎病毒/HCV感染的情况下，由SLC3A2和SLC7A5/LAT1形成的复合物通过促进病毒进入宿主细胞并增加L-亮氨酸摄取介导的mTORC1信号激活，在HCV增殖中发挥作用，从而促进HCV介导的致病机制。 {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) 在未成熟红细胞中作为疟原虫Plasmodium vivax（泰国分离株）的受体。 {ECO:0000269|PubMed:34294905}.
组织特异性
Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1.
亚细胞定位
Apical cell membrane
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