SLC38A1 Q9H2H9

钠耦合中性氨基酸同向转运蛋白1 (氨基酸转运蛋白A1) (N系统氨基酸转运蛋白2) (溶质载体家族38成员1) (A系统氨基酸转运蛋白1) (N系统氨基酸转运蛋白1)

功能描述

同向转运蛋白，将短链中性氨基酸和钠离子从细胞膜外侧共转运至细胞膜内侧 (PubMed:10891391, PubMed:20599747)。该转运是生电性的，依赖于pH，并由Na(+)电化学梯度驱动 (PubMed:10891391)。参与星形胶质细胞来源的谷氨酰胺转运进入GABA能中间神经元，用于神经递质GABA的从头合成 (By similarity)。可能也有助于胎盘滋养层细胞中的氨基酸转运 (PubMed:20599747)。还调节突触可塑性 (PubMed:12388062)。 {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}。

组织特异性

Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis (PubMed:10891391, PubMed:12388062, PubMed:15054072, PubMed:16148032). Highly expressed in cytotrophoblast cells from term placenta (PubMed:20599747).

亚细胞定位

Cell membrane