质子偶联锌反向转运蛋白 SLC30A8 (溶质载体家族30成员8) (锌转运蛋白8) (ZnT-8)
质子偶联锌反向转运蛋白 SLC30A8 (溶质载体家族30成员8) (锌转运蛋白8) (ZnT-8)
Q8IWU4功能描述
质子偶联的锌离子反向转运蛋白，介导锌进入胰腺β细胞分泌颗粒的腔内，从而调节胰岛素分泌。 {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:27875315, ECO:0000269|PubMed:32723473}.
组织特异性
In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.
亚细胞定位
Cytoplasmic vesicle, secretory vesicle membrane
关键词